Scaleup is an essential part of many chemical process operations, and efforts must take into account a variety of engineering, safety and economic considerations. The articles presented in this PDF guidebook focus on specific management strategies that must be undertaken to ensure the most successful scaleup effort.
Here you will find emphasis on the requirements that must be considered when moving promising small-scale chemical reactions and other laboratory developments to full-scale commercial operations. Additional articles focus on overcoming the challenges associated with moving batch operations to continuous operations , a common transition during scaleup efforts.
There is additional coverage on concepts related to managing contractors and sub-contractors, exploiting economies of scale, taking steps to identify and avoid common project-failure modes, carrying out target costing and lifecycle analyses, estimating project costs (including utilities) and more.
These practical, how-to articles were originally published in Chemical Engineering.
Delivered in a PDF format, 77 pages.
TABLE OF CONTENTS:
- How to Estimate Utility Costs
Utility estimates are often complicated because they depend on both inflation and energy costs. This simplified approach offers a two-factor utility cost equation and the relevant coefficients for a number of utilities
- Target Costing
Compliant facilities, delivered at the lowest possible cost, minimize the risk of failure and maximize the return on investment
- Making Sense of Your Project Cost Estimate
Using different estimation levels, determined throughout the engineering phase of a project, can save time and avoid surprises when it comes time to bid
- Avoiding Project Failures
Recognize these key project-failure modes, so that corrective action can be taken
- Project Success Builds On a Well-Defined Scope
Having a clear understanding of what will be included and what will not is fundamental to a project’s success. Time taken to develop a good scope is time well spent
- Accelerating Process and Product Development
These simple strategies can be used to speed up and increase the success rates of R&D projects
- Capital And Production Costs: Improving the Bottom Line
Decisions made in early phases of a project affect production costs for years to come. The disciplined method described here taps into potential savings
- Lifecycle Costs for Capital Equipment In the CPI
Longterm equipment costs need to be fully considered in capital-cost assessments
- From Concept to Commercial Production
These four steps of process development are typically necessary to effectively scale a concept into full production
- A Bit of Extra Lab Effort Can Prevent Grief During Scaleup
The key is persuading the chemist to undertake a little extra data collection
- Troublefree Reaction Scaleup
A chemical-reaction step is usually at the heart of the flowsheet for a new process-industries product. Taking that reaction from the laboratory to the plant is far from simple or straightforward
- Why Big Always Wins: Examining Economies of Scale
Origami teaches one of the fundamental tenets of chemical engineering
- Making the Leap from R&D to Manufacturing
Crafting the right information-management strategy is essential to scaling up promising discoveries
- From Batch to Continuous Processing
Continuous flow reactors can provide many benefits over batch processes. This article answers why and how